The 1627 Gargano earthquake struck Gargano and part of Tavoliere, southern Italy, at about mid-day on 30 July 1627.

A "very large earthquake" caused a major tsunami, the largest seismic event ever recorded in the Gargano region,[4] which "produced severe damage in the whole promontory", killing about 5,000 people.

The most extensive damage was noted between San Severo and Lesina.

Some sources describe a large 1626 Naples earthquake,[6] but other have argued that these are misreports of the 1627 event.

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