16 Biggest Hits is a 2006 Johnny Cash and June Carter Cash compilation album.

It is part of a series of similar 16 Biggest Hits albums released by Legacy Recordings.

[2] It was also released under the title June Carter and Johnny Cash: Duets.

16 Biggest Hits peaked at #26 on the U.S.

Billboard Top Country Albums chart in 2006 and #126 on the Billboard 200.