17β-Hydroxysteroid dehydrogenase

17β-Hydroxysteroid dehydrogenases (17β-HSD, HSD17B) (EC 1.1.1.51), also 17-ketosteroid reductases (17-KSR), are a group of alcohol oxidoreductases which catalyze the reduction of 17-ketosteroids and the dehydrogenation of 17β-hydroxysteroids in steroidogenesis and steroid metabolism.

[1][2][3][4][5] This includes interconversion of DHEA and androstenediol, androstenedione and testosterone, and estrone and estradiol.

17β-HSDs have been known to catalyze the following redox reactions of sex steroids: Genes coding for 17β-HSD include: At least 7 of the 14 isoforms of 17β-HSD are involved in interconversion of 17-ketosteroids and 17β-hydroxysteroids.

Inhibitors of 17β-HSD type II are of interest for the potential treatment of osteoporosis.

[34][40] Some inhibitors of 17β-HSD type I have been identified, for example esters of cinnamic acid and various flavones (e.g.

Steroidogenesis . 17β-HSD visible in bottom-left region.
Distribution of 17β-HSD activities for formation of estradiol versus estrone in human tissues. [ 8 ] [ 9 ]