Elements of the unit engaged in skirmishes with Confederate partisans in Missouri.

The regiment participated in several major actions during Price's Missouri Expedition.

Subsequently, the unit performed garrison duty in Missouri and operations against native Americans in the Great Plains.

On 23 September 1864, they killed Jim Anderson and five other guerrillas near Rocheport, Missouri.

Equipped at Jefferson Barracks and moved to Alton, Ill. Guard prisoners there until August.

1st Battalion, Cos. "A," "B," "C," "D," ordered to St. Louis June, 1864, thence to District of North Missouri.

Engaged in Escort and Provost duty at St. Joseph and Weston, Mo., until June, 1865.

2nd Battalion--"E," "F," "G" and "H"—ordered from Alton, Ills., to Glasgow, Mo., June, 1864, and duty there operating against Thornton's Command until September.

Mine Creek, Little Osage, Marias Des Cygnes, Kansas, October 25.