Elections to the United States House of Representatives were held in Pennsylvania on October 9, 1810, for the 12th Congress.

One Democratic-Republican resigned and was replaced by another Representative from the same party, so that there was still a 16-2 division.

The districts were: Note: Many of these counties covered much larger areas than they do today, having since been divided into smaller counties Fifteen incumbents (14 Democratic-Republicans and 1 Federalist) ran for re-election, of whom ten were re-elected.

All 18 Representatives elected in October appeared in Washington at the start of the 12th Congress.

[5] Abner Lacock (DR) of the 11th district resigned February 24, 1813, after being elected to the Senate.