Senators were elected over a wide range of time throughout 1820 and 1821, and a seat may have been filled months late or remained vacant due to legislative deadlock.

The Democratic-Republican Party gain one-to-five seats (in the general and special elections), assuming almost complete control of the Senate.

Senate party division, 17th Congress (1821–1823) Composition after the June 13 and 14, 1820 elections in Maine.

John Holmes (Democratic-Republican) was elected as one of the new states first pair of senators whose terms began with June 13, 1820, statehood.

William Pinkney won election by an unknown number of votes, for the Class 1 seat.