Senators were elected over a wide range of time throughout 1822 and 1823, and a seat may have been filled months late or remained vacant due to legislative deadlock.

In that election, Senators split into factions in support of William H. Crawford, Andrew Jackson, or John Quincy Adams and Henry Clay.

Senate party division, 18th Congress (1823–1825) Composition after the January 24, 1822 Delaware special election.

Incumbent John Williams Walker resigned on December 12, 1822, due to failing health.

The Delaware General Assembly did not elect a candidate to the United States Senate.

Incumbent Senator Harrison Gray Otis resigned on May 30, 1822, to run for Mayor of Boston.

Governor of New Hampshire Samuel Bell was elected as a Democratic-Republican.Incumbent Democratic-Republican Mahlon Dickerson was reelected in 1823.

Incumbent Democratic-Republican Samuel L. Southard resigned on March 3, 1823, to become the U.S. Secretary of the Navy.

Governor of Ohio, Ethan Allen Brown, was elected to finish Trimble's term.