Elections to the United States House of Representatives were held in Pennsylvania on October 14, 1828, for the 21st Congress.

Pennsylvania was divided into 18 districts, 6 of which were plural districts Note: Several of these counties covered larger areas than today, having since been divided into smaller counties 20 incumbents (15 Jacksonians and 5 Anti-Jacksonians) ran for re-election, of whom 12 (all Jacksonians) were re-elected.

The first was held on October 13, 1829 in the 8th district to fill two vacancies caused by the resignations of Samuel D. Ingham (J) and George Wolf (J) before the first meeting of the 21st Congress.

Wolf's resignation was due to his having been elected Governor of Pennsylvania.

[4] The second was held on December 15, 1829 in the 16th district, to fill a vacancy caused by the resignation of William Wilkins (AM) on November 9, 1829, before the first session of the 21st Congress began.