Season 1880–81 was the fourth in which Hibernian competed at a Scottish national level, entering the Scottish Cup for the fourth time.
Hibs reached the third round of the Scottish Cup, losing 5–3 to Edinburgh derby rivals Hearts.
[1] The match was played in the Powderhall area of Edinburgh.
[1] All results are written with Hibs' score first.
This article about a Scottish association football club season is a stub.