They won the tournament, beating Denton 7–1 in the final at Whalley Range.
[1] Newton Heath LYR entered the Manchester and District Challenge Cup for the fourth time in 1887–88.
It was a tougher match than the previous round, as proven by the 2–0 scoreline, with the Doughty brothers, Jack and Roger, getting a goal apiece.
As with the previous three seasons, the final was played at Whalley Range in south Manchester.
Both Doughtys scored in the final, as they both had done in the two previous rounds, with Jack getting a hat-trick and Roger a brace.