A stagnant economy which became worse after the Panic of 1890, combined with a lack of support for then-Representative William McKinley's (defeated in the election) steep tariff act, which favored large industries at the expense of consumers, led to a sharp defeat for Harrison's Republican Party, giving a large majority to the Democratic Party and presaging Harrison's defeat in the 1892 United States presidential election.

Furthermore, aggressive Republican promotion of controversial English-only education laws enacted by Wisconsin and Illinois in 1889, accompanied by a surge in nativist and anti-Catholic sentiment within the state parties, had greatly hollowed out the party's support base in these former strongholds.

[2] Bitterly divisive struggles over temperance laws had also been alienating immigrants from the increasingly prohibitionist Republican Party across the Midwest more broadly.

Dramatic losses in the previous year's gubernatorial elections in Iowa and Ohio (which would lose another 14 Republican congressional seats between them during this election) were due in no small part to wet immigrant communities, especially Germans, expressing their resentment toward Republican efforts to ban or otherwise curtail alcohol consumption by throwing their support behind the Democratic candidates.

[3] This election also saw the Populist Party, a coalition of farmers and laborers who wanted to overhaul the nation's financial system, make a small mark on Congress.