The 1900–01 St Helens R.F.C.
season was the club's sixth in the Northern Rugby Football Union, the 27th in their history.
In their lowest ever finish in a rugby league competition, coming only a year after their most fruitful one, the club finished 13th in the Lancashire Senior Championship, having two points docked for breach of professional rules in the process.
[1] In the Challenge Cup, the club were knocked out in the third round by Batley.
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