Michigan opened the season with six wins, but went 1–2–1 in the final four games, including losses to Iowa and Chicago.

After the 1900 season, Langdon Lea left Michigan to become the head coach at his alma mater, Princeton.

The great trouble in the past few years has been the lack of efficient coaching, and it is hoped that Lea will supply that necessary.

This practice of putting well known eastern football players in charge of the teams of western universities has certainly improved the standard of play, and in many instances has often wrought havoc with the alma maters of the coaches.

Some years ago the big eastern colleges tried to prevent their graduates from accepting positions as coaches on other teams, but the fat salaries offered were inducements too great to be cast aside.

"[4] Lea brought with him Martin V. Bergen, another Princeton alumnus, as his assistant coach in charge of the backs.

Lea expressed concern with the team's lack of depth at the tackle, guard, and center positions.

[5][6] On September 29, 1900, Michigan opened its season with a 29–0 victory over Hillsdale in front of a crowd of approximately 300 members of the Athletic Association at Regents Field in Ann Arbor.

[7] On October 6, 1900, Michigan defeated Kalamazoo by an 11–0 score at Regents Field in Ann Arbor.

Edward Everett Webber kicked the goal from touchdown to give Michigan a 6–0 lead.

[8][9] On October 13, 1900, Michigan defeated Case Scientific School by a 24–6 score at Regents Field in Ann Arbor.

Michigan scored on touchdowns by Edward Everett Webber, Tom Marks, Frank Boggs, and Ned Begle.

About Case scoring, the fault lies with the line for not holding and with Begle for being too slow punting.

"[10] On October 20, 1900, Michigan opened its Western Conference schedule with an 11–6 win over Purdue before a homecoming crowd of 2,500 at Regents Field.

Right halfback Daniel Woodard scored Michigan's first touchdown, and Sweeley missed the kick for goal.

Left tackle Hugh White scored Michigan's second touchdown, and Sweeley kicked the goal.

[12] On October 27, 1900, Michigan defeated Illinois by a 12–0 score before a crowd estimated at between 8,000 and 10,000 persons at Marshall Field in Chicago.

The game began at 2:43 p.m. Left halfback Daniel Woodard scored Michigan's first touchdown on a two-yard run in the first half, and Everett Sweeley kicked for goal.

Later in the first half, right tackle Hugh White ran one yard for a touchdown, and Sweeley again kicked for goal.

[13] On November 3, 1900, Michigan defeated Indiana by a 12–0 score before a crowd of 2,000 persons at Regents Field in Ann Arbor.

The game was marked by "rough play", including an Indiana player slugging Curtis Redden in the face, though unseen by the umpire.

Right halfback Daniel Woodard scored Michigan's first touchdown on a short run in the first half, and Everett Sweeley kicked for goal.

In the hours before the game began, large numbers of Michigan fans arrived in Detroit and paraded through the city streets behind their band, wearing ribbons, blowing horns, and singing songs.

[16] On November 17, 1900, Michigan defeated Pat O'Dea's Notre Dame team by a 7–0 score at Regents Field in Ann Arbor.

[17] On November 24, 1900, Michigan and Ohio State played to a scoreless tie before a crowd of 3,000 spectators at Regents Field in Ann Arbor.

Ohio utilized "straight football" while on offense with McClaren and Westwater as the main ball carriers.

During the second half, Michigan employed a "tandem formation" in an effort to aggregate sufficient weight to gain ground on the slippery field.

After recovering a fumble deep in Chicago territory, Michigan took a 6-0 lead early in the game on a touchdown by left tackle Hugh White.

[21] After the season, Michigan released its football receipts and expenses, showing a small profit as follows: RECEIPTSIllinois (net) .

320[23]In February 1901, Langdon Lea was hired as Princeton's head football coach, foregoing a contract renewal at Michigan reported to be worth $4,000.