The team compiled a 4–4–1 record and was outscored by its opponents by a combined total of 80 to 71.
Dave Fultz began the season as the team's head coach before resigning after Missouri's season opener, a win over the Kirksville Osteopaths.
He was replaced by Fred W. Murphy, who led the team for the remainder of the season.
[1][2] The team played its home games at Rollins Field in Columbia, Missouri.
This college football 1900 season article is a stub.