Led by third-year head coach Pop Warner, the Indians compiled a 5–7–1 record and was outscored by a total of 168 to 134.

Two Carlisle players received honors from Walter Camp on the 1901 All-America team: Martin Wheelock as a second-team tackle and Jimmy Johnson as a third-team quarterback.

[18] Despite the 16 to 11 Carlisle victory, The Dickinsonian called it "the greatest day in the football history of Dickinson.

"[19] The national champion Michigan Wolverines defeated the Carlisle Indians, 22–0, in a game played at Bennett Park in Detroit on November 2.

[21][22] Starring in the contest was Columbia's backfield of Bill Morley, Harold Weekes, Dick Smith, and Chauncey L. Berrien.