The 1905 Wabash Little Giants football team represented Wabash College as an independent during the 1905 college football season.
Led by second-year head coach Frank Cayou, the Little Giants compiled a record of 6–5.
The team managed one of its most impressive upsets when it defeated Notre Dame, 5–0, on October 21, at South Bend.
It proved to be the Fighting Irish's only home-field loss in 125 games between 1899 and 1928.
This college football 1905 season article is a stub.