The Crimson finished with a 10–1 record under second-year head coach Bill Reid.

The team won its first ten games by a combined 167–20 score, but lost its final game against rival Yale by a 6–0 score.

[1][2] Walter Camp selected only one Harvard player, guard Francis Burr, as a first-team player on his 1906 College Football All-America Team.

[3] Caspar Whitney selected two Harvard players as first-team members of his All-America team: Burr and tackle Charles Osborne.

This college football 1906 season article is a stub.