Football remained a dangerous game, despite the "debrutalization" reforms, and an unprecedented eleven players were killed (9 high school and 2 college), while 98 others were seriously injured.

If the defense committed a foul, the 15 yard penalty didn't apply to the offense, but the defending team was not penalized either.

[3] The Princeton Tigers and Yale Bulldogs had both been unbeaten in 1906, and played to a 0–0 tie at season's end, giving both teams a 9–0–1 record.

Elsewhere in the East, the United States Naval Academy Midshipmen(referred to in the press as Annapolis) and the Carlisle Indian School (coached by Glenn Scobey "Pop" Warner and with Jim Thorpe as its star back) were expected to do well.

In the South, the Vanderbilt Commodores and the Sewanee Tigers of the Southern Intercollegiate Athletic Association (SIAA) were considered contenders, along with Georgia Tech (coached by John Heisman).

[5] Carlisle opened its season early with a 40–0 win over Lebanon Valley on September 21, and Brown beat New Hampshire, 16–0.

Princeton crushed Stevens Tech 47–0, while Harvard was held to a touchdown (then worth five points) in a 5–0 win over Bowdoin.

At West Point, the United States Military Academy (Army) opened its season with a 23–0 win over Franklin & Marshall.

Yale remained unscored upon, but not untied, as it played Army to a 0–0 tie at West Point to "fall" to 4–0–1.

In a highly anticipated game, the Carlisle Indians (7–0–0) met the Princeton Tigers (5–1–0) at the Polo Grounds in New York City on November 2 before a crowd of thousands.

Sewanee defeated the University of Virginia in Norfolk, 12–0, and Pennsylvania hosted Lafayette in Philadelphia, winning 15–0 and extending its record to 8–1–0.

Yale recorded its 8th straight shutout, a 22–0 win over Brown, as Ted Jones returned a punt 90 yards for the first of three touchdowns in the second half.

Yale yielded its first points of the season after the Tigers blocked a punt and Princeton's Booth returned the ball for a touchdown.

Both teams had touchdowns called back by penalties, but Penn scored on an onside kick to hand Michigan its first ever home defeat, 6–0.

[13] November 23 marked the close of the season, as unbeaten Yale (8–0–1) traveled to Cambridge to play its annual game against Harvard.

Carlisle closed its season at the University of Chicago, which had won the title of the Western Conference (later the Big Ten, with a 4–0–0 record.

[15] The catch by Vanderbilt center Stein Stone, on a double pass play then thrown near the end zone by Bob Blake to set up the Honus Craig touchdown that beat Sewanee at the very end, for the SIAA championship was cited by Grantland Rice as the greatest thrill he ever witnessed in his years of watching sports.