Howard & Bullough of Pawtucket were the winners of this edition.

[1] Collingswood, Cameron, Scottish American, and Wilberforce drew byes.

The second round draw took place November 5, 1910 at the Continental hotel in Newark, NJ.

[21] The Ansonia–Brooklyn match was ordered replayed because Ansonia used an ineligible player.

Hibs: GK O'Donnell, RF Danks, LF Wilson(c), RMF Waltermate, CMF Blaney, LMF Tillie, OR Burroughs, IR Godfrey, CF Gallagher, IL Smith, OL Hinds.H&B: GK Healey, RF O'Toole(c), LF Donnelly, RMF Creighton, CMF Brown, LMF Blakely, OR Harvey, IR McKay, CF W.Pemberton, IL E.Pemberton, OL Cannan.