Despite contending for promotion during the first half of the season, injuries dropped the Bees to a mid-table finish.

A £315 loss on the 1909–10 season meant that there was little transfer activity for Brentford manager Fred Halliday to conduct over the course of the 1910 off-season, with half back George Kennedy, full back John Christie and returning outside right Joe Ryalls being the only signings of note.

[1] The Bees had a good first half of the Southern League First Division season, losing just five of the opening 20 matches, with Geordie Reid (Southern League XI) and Steve Buxton and John Christie (both London XI) winning representative honours.

[1] Injuries to George Kennedy, Joe Ryalls, Geordie Reid and George Anderson at differing times disrupted the attack and Brentford finished the season having scored 41 league goals, with Geordie Reid having scored over half the team's total (21),[1] which equalled Adam Bowman's club record for most Southern League goals in a season.

[3] Some pride was salvaged with victory over West London rivals Queens Park Rangers in the inaugural Ealing Hospital Cup in April.