[2] One major change was made to the calculation for the general classification before the start of the second Giro d'Italia.

[5] Of the 101 riders that began the Giro d'Italia on 18 May, twenty of them made it to the finish in Milan on 5 June.

[2] The peloton also contained some of the most famous Italian cyclists at the time in Carlo Galetti, Ezio Corlaita, Giovanni Rossignoli, and Eberardo Pavesi.

[2] The first stage of the second Giro d'Italia began with a large send off in the start city of Milan.

[5][6][7] Dortignacq managed to breakaway from his fellow group member Carlo Galetti and then solo to the stage victory while five other riders chased close behind.

[8] The peloton's pace was slower due to the w poor conditions, which caused the riders to arrive two hours later than expected in Naples.

[2][8] Prior to the fifth stage's start, Frenchman Jean-Baptiste Dortignacq withdrew from the race after citing an illness.

[2][8] The police suspected foul play and looked into the situation, but their results are disputed through contradicting stories.

[9] Ganna went on to win his second consecutive stage, while Galetti extended his lead over the rest of the field.

[9] Eberardo Pavesi dominated the difficult ninth stage that contained the major climbs of the Nava, Tenda, and San Bartolomeo.

[1] Luigi Ganna was the first rider to cross the finish line in Milan and in doing so, he won his third stage of the 1910 Giro d'Italia.