The 1915 Argentine Primera División was the 24th season of top-flight football in Argentina.

The reunification of the "Asociación Argentina de Football" and the "Federación Argentina de Football" brought the creation of a championship of 25 teams.

[1] Clubs that made their debuts in Primera were San Lorenzo de Almagro (Segunda División (AFA) champion)[2] and Defensores de Belgrano (División Intermedia (FAF) champion).

[3] The coming of San Lorenzo caused all the "big five" to meet in an official tournament for the first time.

For the first time in Primera División history, four teams were relegated: Kimberley, Defensores de Belgrano, Comercio and Floresta.