The 1915 Washington University Pikers football team represented Washington University in St. Louis as a member of the Missouri Valley Conference (MVC) during the 1915 college football season.
Led by third-year head coach William P. Edmunds, the Pikers compiled an overall record of 3–2 with a mark of 1–1 in conference play, placing fourth in the MVC.
Washington University played home games at Francis Field in St. Louis.
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