In their fourth year under head coach John Wilce, the Buckeyes compiled a perfect 7–0 record and outscored opponents 258 to 29.

[1] Half of the team's points were tallied in a 128–0 victory over Oberlin.

The 128 points scored against Oberlin remains a single-game Ohio State record.

[2] Halfback Chic Harley was a consensus first-team pick on the 1916 All-America college football team.

[3] Other notable players included end Charles Bolen, center Ferdinand Holtkamp, and tackle Bob Karch.