Republican incumbent Henry Cabot Lodge defeated Democratic Mayor of Boston John F. Fitzgerald to win election to a fifth term.

In 1914 Mayor of Boston John F. Fitzgerald was strongly popular in the city, leading him to consider a challenge against the powerful Senator Lodge.

[2] When he wavered on whether to run for another term in office, however, James Michael Curley entered the race and usurped him in the January 1914 election.

Though he cited illness, he was in fact being blackmailed by Curley and attorney Daniel H. Coakley, who had learned of his indiscretions with a cigarette girl, Elizabeth "Toodles" Ryan.

Lodge focused his campaign on criticism of President Wilson and support for Republican nominee Charles Evans Hughes.