Frank L. Houx Democratic Robert D. Carey Republican The 1918 Wyoming gubernatorial election took place on November 5, 1918.

He ran for re-election and faced a stiff challenge in the Democratic primary from attorney William B. Ross.

After defeating Ross by a decisive margin, he faced Robert D. Carey, the Republican nominee and the son of former Democratic Governor Joseph M. Carey.

However, despite Houx's past electoral success, he faced difficult headwinds as Democratic candidates did poorly across the country in 1918.

He ended up losing re-election to Carey by a wide margin.