After a torrid first season in the Football League, Archie Mitchell joined Brentford as player-manager and the club's squad was overhauled.

[1] Outgoing manager Fred Halliday stayed at Griffin Park as secretary, which allowed Mitchell to focus solely on the team.

[2] New signings Charles Alton and John Bethune bolstered the defence, half backs Charles Fisher and James Kerr came in and Thomas Elliott and Harry Morris were signed to replace the previous season's departed leading goalscorers Harry King and Reginald Boyne.

[3] Brentford began the season inconsistently and hovered around mid-table, before a run of just four defeats in 17 games firmly established the club in the top six by January 1922.

[2] William Young, Harry Anstiss and Freddy Capper missed their train at Paddington and manager Archie Mitchell was pressed into service as an emergency goalkeeper.