In their first season under head coach Wallace Parker, the Central Michigan football team compiled a 7–2–1 record and shut out eight of ten opponents.
The team's victories included games with Ferris Institute (7–0 and 60–0), Olivet College (25–0), Grand Rapids Junior College (7–0), and Alma (29–0).
The team also played Detroit City College to a scoreless tie and lost to the 1921 Michigan State Normal Normalites football team by a close 7–6 score.
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