The 1921 Chattanooga Moccasins football team represented the University of Chattanooga (now known as the University of Tennessee at Chattanooga) as a member of the Southern Intercollegiate Athletic Association during the 1921 college football season.
In their third season under head coach Silas Williams, the Moccasins completed its 10-game schedule with a record of 4 wins and 6 losses.
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