The 1921 Oregon Agricultural Aggies football team represented Oregon Agricultural College (OAC)—now known as Oregon State University—as a member of the Northwest Conference and the Pacific Coast Conference (PCC) during the 1921 college football season.

In their second season under head coach Red Rutherford, the Aggies compiled an overall record of 4–3–2 and outscored their opponents, 231 to 42.

[3] The team played home games at Bell Field in Corvallis, Oregon.

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