The 1921 Oregon Webfoots football team represented the University of Oregon as a member of the Northwest Conference and the Pacific Coast Conference (PCC) during the 1921 college football season.
In their fourth season under head coach Charles A. Huntington, the Webfoots compiled an overall record of 5–1–3 and outscored their opponents 145 to 75.
Oregon had a record of 1–0–3 in Northwest Conference play, placing third, and 0–1–2 against PCC opponents, finishing fifth.
The team played home games on campus, at Hayward Field in Eugene, Oregon.
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