The 1921 PGA Championship was the fourth PGA Championship, held September 27 to October 1 on Long Island at Inwood Country Club in Inwood, New York.

The match play field of 32 consisted of the defending champion and the top qualifiers from the 1921 U.S.

[4][5][6][7] Walter Hagen defeated Jim Barnes, 3 and 2, in the final,[2] for the third of his eleven major titles.

Defending champion Jock Hutchison lost in the second round to Gene Sarazen, 8 and 7.

After not entering in 1922 and losing the final in 1923, Hagen won four consecutive PGA Championships, starting in 1924.