The 1921 Santa Clara Missionites football team was an American football team that represented Santa Clara University as an independent during the 1921 college football season.
The team compiled a 6–0 record, shut out five of six opponents, and outscored all opponents by a total of 224 to 9.
[1] On September 1, 1921, Santa Clara hired Harry G. Buckingham as its football coach.
He played football as a tackle at Princeton and later coached at Colorado School of Mines and Memphis University.
[2] He remained as Santa Clara's football coach for two years.