In its third season under head coach Moon Ducote, the team compiled a 4–4 record.

Three of its losses coming against college football powerhouses, Alabama, Auburn, and LSU.

Spring Hill held both Alabama and LSU to 7–7 ties in the first half of those games.

[1][2] The final game of the season was a 28–7 loss to Mississippi College, which was led by College Football Hall of Fame member Goat Hale.

This college football 1921 season article is a stub.