The 1921 Trinity Blue and White football team was an American football team that represented Trinity College (later renamed Duke University) as a member of the South Atlantic Intercollegiate Athletic Association (SAIAA) during the 1921 college football season.

In its first and only season under head coach James A. Baldwin, the team compiled a 6–1–2 record (0–1 against SAIAA opponents).

Richard Leach was the team captain.

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