The 1921 Washington Senators won 80 games, lost 73, and finished in fourth place in the American League.

They were managed by George McBride and played home games at Griffith Stadium.

Infielders Other batters Note: Pos = Position; G = Games played; AB = At bats; H = Hits; Avg.

= Batting average; HR = Home runs; RBI = Runs batted in Note: G = Games played; AB = At bats; H = Hits; Avg.

= Batting average; HR = Home runs; RBI = Runs batted in Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts Note: G = Games pitched; IP = Innings pitched; W = Wins; L = Losses; ERA = Earned run average; SO = Strikeouts Note: G = Games pitched; W = Wins; L = Losses; SV = Saves; ERA = Earned run average; SO = Strikeouts