Arthur Balfour Unionist Edward Grenfell Unionist The 1922 City of London by-election was a parliamentary by-election held on 19 May 1922 for the British House of Commons constituency of City of London, which covered the "Square Mile" which was the United Kingdom's traditional financial district.

Balfour had held the seat since a by-election in 1906, following his defeat at Manchester East in the 1906 general election.

The Unionist Party selected as its candidate Edward Grenfell, who was a director of the Bank of England.

Sir Vansittart Bowater, who had been Lord Mayor of London in 1913, stood as an Independent Unionist.

Curiously, Bowater would go on to be elected as the official Unionist candidate at a by-election in 1924, and he and Grenfell would share the representation of the City until 1935.