The season was law professor William G. Kline's third and last year as the head coach of the Florida Gators football team.

[4] [1] The lone upset of the year happened in the opening game with a 7 to 6 loss to coach Billy Laval's Furman Purple Hurricane.

Florida had two touchdowns called back and halfback Case once fell down with a clear field in front of him.

[18] Facing many former college football stars, including Hall of Famer Buck Flowers, who netted a 74-yard punt during the contest, Florida defeated American Legion 14–0 in Tampa using much of the new style of play.

[21] In the Gators' first ever game against a traditional northeastern college football power, they traveled north to meet coach Bob Fisher's Harvard Crimson.

[22] Harvard subs overwhelmed the Florida team 24 to 0 in front of the largest crowd yet to see the Gators play.

One writer spoke of "the desperate rally of Florida's 'Gators against the overwhelming Harvard attack" which despite the loss "showed the 'Gators probably the best team the Gainesville institution has turned out.

[24][25] In Tampa on Plant Field, the Gators defeated coach Stanley L. Robinson's Mississippi College Choctaws 58 to 0.

[28] In the seventh week of play, Florida defeated coach Clark Shaughnessy's Tulane Green Wave in New Orleans 27 to 6 in an upset.

[29][31] Freezing weather and a stony field in Atlanta made for unexpected trouble against the Oglethorpe Stormy Petrels.

[40] The 1922 freshman team was a Southern champion, coached by Florida native and former Yale All-American John Acosta.

[41][n 1] After the 1922–1923 school year, Kline resigned to pursue a legal career,[42] and returned to the University of Nebraska, where he was the head coach of the Nebraska Cornhuskers basketball and baseball teams, and later became a published author of books on coaching football, basketball and baseball.