The league championship was won by the Canton Bulldogs, the first of two back-to back titles.
Technically, it was also Green Bay's first full season in the league, after their membership was suspended because the team had fielded college players in 1921.
They returned to the original name a year later; most teams around the league continued to call them the Packers.
The Muncie Flyers, Cleveland Indians, Brickley's New York Giants, Cincinnati Celts, Tonawanda Kardex, Washington Senators, and Detroit Tigers dropped out of the league.
The Canton Bulldogs were named the 1922 NFL Champions after ending the season with a 10–0–2 record.