First-seeded Molla Mallory defeated Helen Wills 6–3, 6–1 in the final to win the women's singles tennis title at the 1922 U.S. National Championships.

The event was held at the West Side Tennis Club, Forest Hills, New York City.

It was Mallory's seventh U.S. National singles title.

[1] Mallory won the tournament without losing a set.

[2][3]