Frank B. Kellogg Republican Henrik Shipstead Farmer–Labor The 1922 United States Senate election in Minnesota took place on November 7, 1922.

Senator Frank B. Kellogg and Democratic challenger Anna Dickie Olesen.

Olesen was the first woman nominated by a major political party in an election to the United States Senate.

She was furthermore the first woman nominated by the Minnesota Democratic Party in any statewide election, and, together with the 1922 Farmer–Labor nominees for Secretary of State and State Auditor, Susie Stageberg and Eliza Evans Deming, tied for the record for second woman nominated by a major political party in a statewide election in Minnesota (the first being the 1920 Farmer–Labor nominee for Secretary of State, Lily J. Anderson).

Additionally, in the 1922 United States Senate election in Minnesota, Kellogg became the first Republican incumbent representing Minnesota in the United States Senate to ever be defeated, in a bid for re-election, by a non-Republican.