The season included a tie with Michigan at the dedication of the new Dudley Field; the first stadium in the South to be used exclusively for college football.

[15] Fifteen starters returned from the previous season[17] including: Neely, Doc Kuhn, Percy Conyers, Alfred Sharp, Tot McCullough, Hugh Mixon, Hek Wakefield, Red Rountree, Freddie Meiers, Tex Bradford, and Fatty Lawrence.

Newcomers included guard Garland Morrow and halfback Gil Reese – who was given particular attention from first-year backfield coach Lewie Hardage.

[19] After last season, the yearbook noted the Commodores "should have a good chance to repeat the splendid record of '21", expecting to lose just captain Pink Wade[n 3] and Fats Bailey to graduation.

[23] Last season's leading scorer Rupert Smith also did not return; neither did end and punter Thomas Ryan, who preferred to remain at his job in the oil industry in Tampico, Mexico.

[24] The team also lost tackle Pos Elam, who decided to attend the Middle Tennessee State Normal School.

[39] As well as Reese, game accounts praise quarterback Doc Kuhn and halfback Freddie "Froggy" Meiers for displaying skill while sprinting around broken fields.

Vanderbilt was sluggish in the first half, which saw Doc Kuhn, Alvin Bell, and Freddie Meiers each play quarterback, but apparently failing to find a rhythm.

The only points scored during the half was a 70 yd (64 m) touchdown run in the first quarter as Commodore halfback Gil Reese darted through the entire Henderson-Brown defense.

"[49] Another account reads: "Thousands of cheering Vanderbilt fans inspired the surge of center Alfred Sharp, guard Gus Morrow, tackle Tex Bradford, and end Lynn Bomar, who stopped Michigan cold in four attempts.

"[57] Also reported, probably more accurately,[64][65] as: "Out there lie the bones of your grandfathers ... and down on that field are the grandsons of the Yankee soldiers who put them there", referring to a nearby military cemetery.

Michigan's consensus All-American halfback Harry Kipke had been rendered moot for most of the game and later said: "I picked myself up very, very painfully from every blade of grass in the place.

[70] According to the 2012 Vanderbilt Football Fact Book, the tie was preserved when captain Neely recovered a fumble near the Commodore goal.

[86] Several key Vanderbilt players were injured: Neely, Morrow, and McCullough all experienced problems, leading to a significantly shortened playing time.

[85][91] Doc Kuhn was praised for his contributions to the run game and his generalship at the quarterback position, as was Scotty Neill for his punting.

[103] Replacement quarterback Red Rountree was the star of the game, making possible all four of the Commodores' scores with his punt returns and end runs.

The second touchdown came after a short punt from Mercer and a good return from Rountree set up a line buck into the end zone from Bomar.

[95] In the sixth game of the year, Vanderbilt beat the Tennessee Volunteers at Knoxville, 14–6 "principally due to the fact that Neill was able to outkick the great Campbell.

[107][112] After the game, Neilly, Lynn Bomar, Gil Reese, and Fatty Lawrence were all mentioned as the Commodores' best players; Campbell was cited as the star for the Volunteers.

[111] The Nashville Banner said Lawrence had been "in there doing a man's job blocking a kick and tackling with the deadliness of a tiger unleashed in a cave of lions.

[114][119] The Commodore's first drive of the second quarter centered around Kuhn, Meiers, and Jess Neely; but after reaching Kentucky's 35-yard line the ball was turned over on downs.

[133] Every Georgia opponent had failed to score through its line during the 1920 and 1921 seasons,[22] but the Bulldogs had defended the forward pass poorly in prior weeks.

Vanderbilt also had a play where, after a fair catch, the team lined up as if they were prepared to punt, and tried to recover a high, hanging onside kick from scrimmage.

[126] To start the second half, Dave Collings kicked off to Freddie Meiers, who had the best run of the day with a return of 40 yards (37 m), giving Vanderbilt the ball at the 45-yard line.

[126][128] Vanderbilt finished the season on November 30, Thanksgiving Day, with a game against its oldest rival, the Sewanee Tigers, at Dudley Field.

[140] This led to Vanderbilt's first scoring drive, which was marked by dashes around end from Gil Reese and powerful runs off-tackle by Freddie Meiers.

After Meiers failed to gain on the next play,[140] Reese carried the ball for a score on a flank attack,[141] and Hek Wakefield kicked the extra point.

Vanderbilt put together another scoring drive, this time started by Meiers running through Sewanee's line for a long gain.

Vanderbilt's defense responded again, throwing Gibbons for a loss, and Sewanee's attempted field goal from the 11-yard line narrowly missed.

[174] The following chart provides a visual depiction of Vanderbilt's lineup during the 1922 season with games started at the position reflected in parentheses.