Illinois (coached by Bob Zuppke) and Michigan (coached by Fielding "Hurry-Up" Yost), both members of what is now the Big Ten Conference, finished with records of 8–0 and were selected as national champion by multiple selectors.

Southern Methodist University (SMU) had a record of 9–0, thanks to coach Ray Morrison bringing the forward pass to the southwest.

September 29 Notre Dame opened its season with a 74–0 win over visiting Kalamazoo College.

After a warmup game against a team of Cal alumni, California beat St. Mary's 49–0.

At Portland, Oregon, California continued its streak of shutouts with a 9–0 win over Washington State.

November 3 Yale beat Army 31–10 Notre Dame beat Purdue 34–7 Dartmouth (5–0–0) hosted Cornell (4–0–0) and in a triumph of Big Red over Big Green, Cornell won 32–7.

Illinois and Chicago, both unbeaten (4–0–0) met at Champaign, with the Illini winning 7–0.

California held visiting Nevada scoreless for its seventh straight shutout, but could not score either, suffering a 0–0 tie.

Illinois beat Mississippi State 27–0, and Michigan won at Wisconsin 6–3, as both teams stayed unbeaten.

Dartmouth beat Colby College 62–0, and Cornell defeated Johns Hopkins 52–0.

In Philadelphia, Cornell closed a perfect season with a 14–7 win over Pennsylvania.

Kansas and Missouri played to a 3–3 tie, giving the Jayhawks an unbeaten, if not untied (5–0–3) finish.

A crowd of 48,000 turned out to watch Navy and Washington play an exciting game.

Ira McKee's passing put Navy ahead 14–7 at halftime, after Washington's George Wilson had tied the game at 7–7.

In the fourth quarter, Washington's Roy Petrie picked off a pass at Navy's 10 yard line, setting up the Huskies' tying touchdown for a 14 to 14 finish.

[4] Later, it turned out that Washington halfback Les Sherman, whose two extra point attempts had tied the game, had played with a broken toe, while fullback Elmer Tesreau had played with a fractured leg.