The 1925 Rock Island Independents season was their sixth and final season in the league.
The team failed to improve on their previous league record of 5–2–2, losing three NFL games.
[1] They finished eighth in the league.
[2] * The Pottsville Maroons were suspended from the league in December, resulting in the Chicago Cardinals being named the NFL champions.
This article relating to an American football season is a stub.