Nelson ended the season with a record of 22 wins, 7 draws and 13 defeats, helping the team to a total of 51 points.

In the 1926–27 season, Nelson recorded several large victories, including a 7–0 win over Accrington Stanley and a 7–1 defeat of Crewe Alexandra.

Nelson were consistently near the top of the league table throughout the campaign, but were never able to supplant Stoke City from the top position, and a run of six consecutive losses at the end of the season saw them finish in fifth-place in the league.

Nelson used 24 different players during the season, many of whom had also played for the club during the previous campaign.

The highest attendance of the season at the club's Seedhill stadium was 12,415 for the 1–0 win over Bradford (Park Avenue) on 12 February 1927, while the lowest gate was 2,385 for the final game of the season against Tranmere Rovers.