The 1929 Cal Poly Mustangs football team represented California Polytechnic School—now known as California Polytechnic State University, San Luis Obispo—as a member of the California Coast Conference (CCC) during the 1929 college football season.
Led by ninth-year head coach Al Agosti, Cal Poly compiled am overall record of 3–5 with a mark of 0–2 in conference play.
The Mustangs played home games in San Luis Obispo, California.
Cal Poly was a two-year school until 1941.
The Mustangs did not field a team in 1930 due to the polio epidemic.