After the fourth victory (third in a row) of Alfredo Binda in the 1929 edition, organizers paid him 22,500 lire (a sum equal to the prize for the overall winner) to not take part in the race.

There were six teams that competed in the race: Bianchi-Pirelli, Dei-Pirelli, Gloria-Hutchinson, Legnano-Pirelli, Maino-Clément, and Prina-Hutchinson.

[2] Four-time winner and reigning champion Alfredo Binda did not compete in this running of the Giro because the organizers felt he was too dominant and paid his team manager 22,500 lire — the same amount as the first place rider would receive that year — to keep Binda off the start list.

Aristide Cavallini won the prize for best ranked isolati rider in the general classification.

[4] Marchisio, who received medical care on his eye in Palermo, stated later the doctor advised him to abandon the race, but he then said: "Losing my sight is one thing, but not winning the Giro would really have bothered me.