This was the first of four consecutive Senate elections during the Depression in which Democrats made enormous gains, achieving a cumulative pick-up of 34 seats.

The Republicans therefore retained the plurality of seats at the beginning of the next Congress (with Vice President Charles Curtis (R) able to cast tie-breaking votes, the Republicans would have majority control).

Seven Republicans and five Democrats sought re-election but lost in the primary or general election.

As of 2023[update], this is the last time a Republican has won the Class 2 Senate seat in Rhode Island, and it would be the last time a Republican would win any Senate seat in the state at all until John Chafee in 1976.

William E. Brock Democratic Cordell Hull Democratic William E. Brock was not a candidate to the next term, instead choosing to return to his Chattanooga candy manufacturing business.