Margaret Scriven defeated Simonne Mathieu in the final, 6–2, 4–6, 6–4 to win the women's singles tennis title at the 1933 French Championships.

[1] It was the only time an unseeded player won the title until Jeļena Ostapenko did so in 2017.

[2] The seeded players are listed below.

Margaret Scriven is the champion; others show the round in which they were eliminated.