Fred Perry defeated Jack Crawford 6–3, 11–13, 4–6, 6–0, 6–1 in the final to win the men's singles tennis title at the 1933 U.S. National Championships.

[2] It was Perry's first Grand Slam title overall, and the first of three U.S. Championships.

Crawford was attempting to complete the Grand Slam.

The tournament used two lists of eight players for seeding the men's singles event; one for U.S. players and one for foreign players.

Fred Perry is the champion; others show the round in which they were eliminated.